Progesterone levels decrease throughout the last day of oocyte maturation

Progesterone levels decrease throughout the last day of oocyte maturation

In general, and in ovarian stimulation treatments prior to in vitro fertilization, it has been observed that progesterone levels may rise. Although there is some controversy as to the effect this fact may have on the pregnancy rate, it is believed that it could have a negative impact on the endometrium when these levels exceed 1.5 ng / ml in fresh cycles. For this reason, the embryo transfer is usually postponed in cases where this value is exceeded.

However, a group of researchers from the Dexeus Mujer's Reproduction Medicine Service, led by Dr. Nikolaos Polyzos and Dr. Iñaki González Foruria, has conducted a study to see if these levels may experience variations throughout the day. To do this, it carried out various measurements of this parameter in a total of 22 egg donors who were performing an ovarian stimulation treatment. The study was conducted in two months (from November 2017 to January 2018). Its objective was to check if there were significant differences. Progesterone levels were measured four times on the same day: at 8:00 a.m., 12 noon; 4:00 p.m. and 8:00 p.m.

The results showed that progesterone values decreased significantly and that the difference between 8:00 a.m. and 8:00 p.m. was equivalent to a decrease of 44%, a fact that could be related to the dose of follicle stimulating hormone (FSH) administered. According to the authors, these data suggest that a single measurement of the levels of this hormone on the last day of oocyte maturation is not enough to make clinical decisions due to the progesterone variations recorded throughout the day. However, they indicate that more studies are needed to better define the impact of the increase in this hormone on the endometrium.

Clinically significant intra-day variability of serum progesterone levels during the final day of oocyte maturation: a prospective study with repeated measurements

González-Foruria I1, Rodríguez I1, Martínez F1, Rodríguez-Purata J1, Montoya P1, Rodríguez D1, Nicolau J1, Coroleu B1, Barri PN1, Polyzos NP1,2,3.
Hum Reprod. 2019 Aug 1; 34(8):1551-1558. doi: 10.1093/humrep/dez091.